About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onLinkedIn,Facebook,Instagram,XandYouTube.

The Biotherapeutics and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities.You will serve as a subject matter expert in oligonucleotide chemistry and siRNA production, with responsibility for generating high-quality siRNA materials to advance genetic medicine studies.

Responsibilities:

• Lead the siRNAsynthesis platformto supportvarious stages of siRNA studies.
• Oversee solid-phase oligonucleotide synthesis, deprotection, purification, desalting, and analytical characterization of siRNA.
• Troubleshoot synthesis, purification, and analytical challenges to improve yield, purity, and scalability.
• Partner with cross-functional teams, including the siRNA screening team, the antibody conjugation group, and CMC, to support platform and project objectives.
• Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
• Track and evaluate emerging technologies and best practices inoligonucleotide and RNA-based therapeutics.
• Manage and develop a team of 23 scientists to support program goals and deliver high-quality siRNA materials on time.

• BS, MS, or PhD in chemistry, chemical biology, biochemistry, or a related field,with typically 6+ (PhD), 12+ (MS), or 14+ (BS) years of experience in biotech or pharma.
• Demonstrated expertisein siRNA synthesis, purification, and characterization.
• Strong knowledge of oligonucleotide chemistry, RNA chemistry, conjugation chemistry, and analytical techniques such as HPLC, LC-MS, and UV spectroscopy.
• Demonstrated ability to independentlyaddresscomplex technical problems and drive projects forward.
• Excellent communication, collaboration, and organizational skills.
• Strongtrack record of presenting complex scientific data to internal and external stakeholders.
• Prior people management experience is a plus.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible toparticipatein our short-term and long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html